The main goal of the project
Based on application of research results, the presented project aims to examine in detail the issue of hereditary cancer caused by Lynch syndrome and to investigate into the presumed genetic background of the higher prevalence of selected types of cancer in the Slovak population. An important project objective is also the development of prototypes of novel, less invasive cancer screening methods based on liquid biopsy.
The subject of the project
The introduction of non-invasive screening tests involving innovative molecular methods would improve the adherence of individuals at higher risk of colorectal cancer to the established screening regimen. This should lead to higher efficiency in preventing the development of colorectal cancer or possibly other cancers associated with Lynch syndrome, resulting in an overall improvement in the health of the general population.
Determining the population frequencies of pathogenic variants in the genes of the mismatch repair system will allow us to better understand the contribution of genetic factors to the incidence of colorectal cancer in the Slovak population.
Long-term strategic research and development focused on the incidence of Lynch syndrome in the Slovak population and the possibilities of prevention of cancers associated with this syndrome.
Research activity under the PreveLynch project
Development of prototypes of novel less invasive cancer screening methods based on liquid biopsy.
The intention of the PreveLynch project
Clarifying the relevance of the genetic component in the incidence of colorectal cancer (CRC) in Slovakia, the introduction of modern non-invasive screening tests and defining of appropriate screening in our population will reduce the incidence and mortality of CRC and other Lynch-associated cancers, increase the quality of life and will also reduce sickness absence as well as curtail treatment expenditures nationwide.
The activities will lead to issuing of 30 publications prepared within the scope of the project.